diff --git a/lib/response.js b/lib/response.js
index 5046395..6c663a7 100644
--- a/lib/response.js
+++ b/lib/response.js
@@ -85,7 +85,7 @@ module.exports = {
     assert(!this.res.headersSent, 'headers have already been sent');
     this._explicitStatus = true;
     this.res.statusCode = code;
-    this.res.statusMessage = statuses[code];
+    if (this.req.httpVersionMajor < 2) this.res.statusMessage = statuses[code];
     if (this.body && statuses.empty[code]) this.body = null;
   },
 
diff --git a/test/response/status.js b/test/response/status.js
index 6b7eb07..9b74612 100644
--- a/test/response/status.js
+++ b/test/response/status.js
@@ -44,6 +44,17 @@ describe('res.status=', () => {
         assert.doesNotThrow(() => response().status = 700);
       });
     });
+
+    describe('and HTTP/2', () => {
+      it('should not set the status message', () => {
+        const res = response({
+          'httpVersionMajor': 2,
+          'httpVersion': '2.0'
+        });
+        res.status = 200;
+        assert(!res.res.statusMessage);
+      });
+    });
   });
 
   describe('when a status string', () => {